งานวิจัย

การประเมินเทคโนโลยีสุขภาพเพื่อการผลิตนวัตกรรมสำหรับการตรวจคัดกรองผู้ป่วยวัณโรคชนิดไม่ใช้ตัวอย่างเสมหะ

มีนาคม 4, 2024

ข้อมูลงานวิจัย

Tuberculosis remains a major healthcare burden in Thailand. One problem with tuberculosis management is inaccurate diagnosis due to insufficient sensitivity and specificity of the current routine diagnostic tests, including sputum-smear microscopy and chest radiography. In addition, because of the nature of the procedure, sputum collection in children requires extensive and costly procedures, such as anesthetic administration.

To address these challenges, the medical innovator team under Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, has proposed to develop a non-sputum-cased assay with high sensitivity and specificity in detecting tuberculosis, utilizing loop-mediated isothermal amplification technology coupled with chromatographic visualization on a lateral flow dipstick. MIDAS and MORU are working in collaboration to evaluate this novel technology in development to identify its value proposition and use case of this new tuberculosis test, as well as to examine the cost, clinical usefulness, and health gain of adopting the new test in Thailand.

The early health technology assessment of this non-sputum-based assay for screening and treatment monitoring of tuberculosis will provide the necessary information to the innovators, such as target product profiles, such as cost-effectiveness, to efficiently develop the new screening and treatment monitoring tool for tuberculosis. In addition, early health economic evaluation of this technology will provide insights into the clinical and social benefits of implementing this technology in Thailand’s healthcare system.    

Associate organization

Researcher

นพ.ยศ ตีระวัฒนานนท์
ผู้อำนวยการร่วม
ซือ กั๋วหมิง
ผู้ช่วยวิจัย
Dr. Wang Yi
ผศ. ดร.หวัง อี้
ผู้อำนวยการร่วม